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  • Writer's pictureChristina Cunningham Spinler

Anxiety and your brain

The Neurobiology of Anxiety: A Look Inside the Human Brain and Nervous System

When the human body senses danger or discomfort, a cascade of physiological responses is set in motion, resulting in the feeling of anxiety. This complex emotional response is orchestrated by the brain and nervous system. Understanding the neurobiology of anxiety provides critical insight into how the brain processes stress and fear, and how these processes may go awry, resulting in chronic or debilitating anxiety disorders.

The Central Role of the Amygdala

At the core of our anxiety responses is a small, almond-shaped structure deep in the brain known as the amygdala. The amygdala serves as a crucial hub in the processing of emotional stimuli, particularly fear and anxiety. It assesses incoming sensory information, determines whether a threat is present, and coordinates appropriate behavioral responses.

When the amygdala detects a potential threat, it triggers an alarm system within the brain, prompting a series of processes intended to protect the individual from harm. It communicates with various regions of the brain, such as the hypothalamus, the prefrontal cortex, and the hippocampus, to facilitate these responses.

The Hypothalamic-Pituitary-Adrenal (HPA) Axis

The hypothalamus, upon receiving the 'threat signal' from the amygdala, stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then prompts the adrenal glands to produce cortisol, a stress hormone that primes the body for a 'fight or flight' response. This series of interactions, known as the hypothalamic-pituitary-adrenal (HPA) axis, plays a vital role in our stress response.

The surge in cortisol has several physiological effects. It increases glucose in the bloodstream, enhances the brain's use of glucose, and suppresses non-emergency bodily functions like the immune response and digestion. It also communicates with the brain to modulate fear and anxiety responses.

The Role of the Prefrontal Cortex and Hippocampus

While the amygdala and HPA axis are initiating the stress response, other parts of the brain are involved in modulating and controlling this reaction. The prefrontal cortex, a region associated with higher cognitive functions like decision-making and social behavior, plays a crucial role in assessing the actual level of threat and regulating the emotional response initiated by the amygdala.

The hippocampus, known for its role in memory, also plays a role in anxiety. It helps to contextualize the fear or threat, relating it to past experiences. This process can either amplify or dampen the anxiety response, depending on whether past experiences were perceived as threatening or safe.

The Neurotransmitter Equation

At the neurochemical level, several neurotransmitters, or chemical messengers in the brain, are involved in the regulation of anxiety. These include serotonin, gamma-aminobutyric acid (GABA), and noradrenaline.

Serotonin is known to have a calming, mood-stabilizing effect, and alterations in serotonin signaling are implicated in many anxiety disorders. GABA, the brain's primary inhibitory neurotransmitter, plays a crucial role in anxiety by reducing neuronal excitability. Reduced GABA activity is associated with heightened anxiety.

Noradrenaline (norepinephrine) is associated with the 'fight or flight' response and can increase alertness and arousal. Overactivity in the noradrenergic system can lead to excessive anxiety.

While anxiety is a natural human response, chronic or excessive anxiety can interfere with daily life and may indicate an anxiety disorder. Understanding the complex interplay between different brain regions, the HPA axis, and various neurotransmitters in the generation of anxiety responses can inform treatment strategies and help in the development


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